dMRI preprocessing

Challenge

Complexity and lack of standardization of preprocessing can induce bias in interpretation of dMRI.

Consequences of failing to reorient the b-vector in dMRI Leemans and Jones (2009), Magnetic Resonance in Medicine
Consequences of bvec axis flip in dMRI Aganj (2018), Scientific Reports

Solution

Automatically apply best practices for dMRI preprocessing using QSIPrep:

  • Robust
  • Reproducible
  • Interrogable "glass box" architecture
  • packaged as a BIDS App

Cieslak et al. QSIPrep: an integrative platform for preprocessing and reconstructing diffusion MRI data. Nat Methods 18, 775–778 (2021).

The qsiprep preprocessing workflow

TLDR: Diffusion preprocessing is hard. Use QSIPrep to do it right!